Published on 24 May 2024 on Zacks via Yahoo Finance
Verastem Oncology VSTM announced positive interim safety and efficacy data from the dose level 1 cohort of its early to mid-stage study evaluating avutometinib and defactinib in combination with standard-of-care first-line chemotherapy (gemcitabine and Nab-paclitaxel) in metastatic pancreatic cancer patients.
Both avutometinib and defactinib have been in-licensed by Verastem from other pharmaceutical companies. Avutometinib is an RAF/MEK clamp, while defactinib is a best-in-class selective FAK inhibitor.